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Jigsaw has disappeared. Along with his new apprentice Amanda, the puppet-master behind the cruel, intricate games that have terrified a community and baffled police has once again eluded capture and vanished. While city detectives scramble to locate him, Doctor Lynn Denlon and Jeff Reinhart are unaware that they are about to become the latest pawns on his vicious chessboard.
Despite Jigsaw's death, and in order to save the lives of two of his colleagues, Lieutenant Rigg is forced to take part in a new game, which promises to test him to the limit.
Following Jigsaw's grisly demise, Detective Mark Hoffman is commended as a hero, but Agent Strahm is suspicious, and delves into Hoffman's past. Meanwhile, another group of people are put through a series of gruesome tests.
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Two men wake up to find themselves shackled in a grimy, abandoned bathroom. As they struggle to comprehend their predicament, they discover a disturbing tape left behind by the sadistic mastermind known as Jigsaw. With a chilling voice and cryptic instructions, Jigsaw informs them that they must partake in a gruesome game in order to secure their freedom.