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June, a young orphan, is befriended by Perry Bascom when he shares his lunch with her on the road to Rising Sun. They soon fall in love and marry, only to find out that a woman in Perry's past has come to town to make trouble. Teaming up with the local political bully, the schemers set out to make Perry's life miserable, but June sticks by her husband to the end.
George Anderson, a struggling author, works in the daytime as a clerk in the office of Emmet Standish, the publisher, and at night writes on his novel, "The Mortal Sin."
Evelyn and her boyfriend William Bard are members of a small Shaker community. They rock the community one day when they announce that they want to get married and have children, in direct opposition to the Shaker prohibition against marriage and procreating. The Shakers drive the couple out of town, but before she leaves Evelyn gives birth to a daughter, Eve. Shortly afterward Evelyn dies, and the Shakers inform William that their daughter Eve has died also. William leaves town, but vows to take his revenge on the Shakers, whom he blames for the loss of his family.
Echo, the orphaned "flower of no man's land," has been raised by an Indian foster father, Kahoma. Then, when opera singer Roy Talbot goes West to recover his health, Echo falls instantly in love and forgets all about Big Bill, her cowboy sweetheart. Roy marries Echo and takes her back East, but soon after returning to his adoring public, he loses all interest in her. Finally, Echo leaves Roy and goes back to the wilderness, where she discovers that Roy had already been married when they met and had deserted his wife years before. For so deceiving his adopted daughter, Kahoma tracks Roy down and kills him, while Echo forgets about her big-city unhappiness and returns to Big Bill, with whom she makes plans to marry.
Blind Ambrose North is tormented by the suspicion that his wife Constance committed suicide when their crippled daughter Barbara was only two, because she did not love him. Before her death, Constance wrote Barbara a letter to be opened on the girl's twenty-first birthday, but when Barbara opens it and learns that her mother killed herself to escape a doomed love affair with Lawrence Austin, she invents a different story for Ambrose, knowing that the truth would hurt him too deeply.
Viola Dana plays Eleanor, a minister's daughter who comes to New York to visit her older sister, a successful businesswoman. Eleanor manages to get a job as a nurse in a major metropolitan hospital. One night, she is called upon to look after a drunken tourist, who turns out to be her hometown sweetheart Roger (Pat O'Malley).
An illegitimate child of the slums comes to faith. Later, she chooses to labor in a canning factory in order to investigate its poor conditions, not realizing she has a significant connection to the cold-hearted factory owner.
Tangletop, is the daughter of the town drunk with her tattered clothes and unkempt hair has been made a social outcast. As a result, she seems to be the perfect actress for the role that Emmett Dwight has developed in order to deceive his wealthy ward, Lowell Van Orden, who, during his blindness, fell in love with Mollie Dean. Since Emmett wants his daughter Madeline to marry Lowell, he tells his ward, after his eyesight has been restored, that Tangletop, who gladly goes along with the plan, is Mollie. As Emmett hoped, his ward's ardor starts to cool, but then, after Tangletop comes under the influence of the Reverend Clyde Harmon, she confesses everything to Lowell. As soon as she finishes, Lowell seeks out the real Mollie and marries her, after which Tangletop marries Clyde.
As a baby, Patsy Smith is kidnapped by her father following a bitter quarrel with her mother. After her father dies at sea, a seafarer named Captain Barnaby places Patsy at Mrs. Duff's boardinghouse. She grows up working as a domestic drudge, deeply unhappy with her life. Inspired by Captain Barnaby's storytelling about Aladdin, Patsy sets out to find an old Oriental lamp that once belonged to her father. She learns that Mrs. Duff sold it to a junk peddler and goes to buy it back. Patsy rubs the lamp, unleashing a Genie. The Genie helps Patsy by providing her with fine clothing, exposing her abusive boardinghouse mistress, and eventually reuniting Patsy with her long-lost mother. With her life transformed, Patsy also finds romance with Harry, a young man who resides at the boardinghouse.