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A prominent banker commits suicide. His son thinks otherwise and sets out to prove it.
Dick Tracy's foe for this serial is the crime boss and Masked Mystery Villain The Spider/The Lame One and his Spider Ring. In the process of various crimes, including using his Flying wing and sound weapon to destroy the Bay Bridge in San Francisco and stealing an experimental "Speed Plane", the Spider captures Dick Tracy's brother, Gordon. The Spider's minion, Dr. Moloch, performs a brain operation on Gordon Tracy to turn him evil, making him secretly part of the Spider Ring and so turning brother against brother.
'Firebrand' Jordan is a ranger sent into the high Sierras to assist the local Sheriff Ed Burns in capturing a mysterious band of counterfeiters.
A milquetoast Easterner who on a trip to the Wild West is mistaken for a U.S. marshall.
Bill Sommers returns to find his ranch threatened by a corrupt, water-stealing landowner, John Weston. Weston’s foreman, Ballon, commits murder, frames Bill, and forces him to fight to clear his name.
A cowboy finds himself blamed for a series of crimes he didn't commit, so he sets out to find the real criminal.
Unable to pay her notes, Ann Bradford, owner of the Circle C, decides to auction off a half-interest in her ranch. Matt Stark, a crooked land dealer, holds Ann's notes. His efforts to buy the ranch have been refused and his instructs his henchman, Barlow, and his other henchmen to make certain that nobody bids on the ranch. Clint Buckley rides into town on the day of the auction, overhears Stark's instructions to his henchies, and decides to attend the sale. Barlow attempts to intimidate him, they fight, Buckley wins and his bid of $25,000 wins him a half-interest in the Circle C. But, Stark, isn't finished yet in his efforts to get the ranch, especially since a couple of his hirelings are on the Circle C payroll.
An internationally-notorious criminal scientist returns to the US to sell his latest invention, a disintegrating gas, to a foreign power. When he arrives, however, he is spotted by a young Coast Guard man, whom he kills - and thus earns the enmity of the entire US Coast Guard, but especially the murdered Guardsman's older brother who, together with his reporter-girlfriend and her comical photographer, vigorously sets to tracking him down and interfering with his plans to develop the city-melting gas in quantity. A Republic Serial in 12 Chapters.
A cowboy goes after a gang of stagecoach robbers who murdered his brother.
Three men escape from prison, go back to their hometown to try to find out who framed them.