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George Bailey has spent his entire life giving to the people of Bedford Falls. All that prevents rich skinflint Mr. Potter from taking over the entire town is George's modest building and loan company. But on Christmas Eve the business's $8,000 is lost and George's troubles begin.
A runaway heiress makes a deal with the rogue reporter trailing her but the mismatched pair end up stuck with each other when their bus leaves them behind.
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A New York gangster and his girlfriend attempt to turn street beggar Apple Annie into a society lady when the peddler learns her daughter is marrying royalty.
Longfellow Deeds lives in a small town, leading a small town kind of life. When a relative dies and leaves Deeds a fortune, Longfellow moves to the big city where he becomes an instant target for everyone. Deeds outwits them all until Babe Bennett comes along. When small-town boy meets big-city girl anything can, and does, happen.
Alice, the only relatively normal member of the eccentric Sycamore family, falls in love with Tony Kirby, but his wealthy banker father and snobbish mother strongly disapprove of the match. When the Kirbys are invited to dinner to become better acquainted with their future in-laws, things don't turn out the way Alice had hoped.
British diplomat Robert Conway and a small group of civilians crash-land in the Himalayas, where they are rescued by the inhabitants of the hidden, idyllic valley of Shangri-La. Protected by the mountains from the world outside, where the clouds of World War II are gathering, Shangri-La provides a seductive escape for the world-weary Conway.
As a parting shot, fired reporter Ann Mitchell prints a fake letter from unemployed "John Doe," who threatens suicide in protest of social ills. The paper is forced to rehire Ann and hires John Willoughby to impersonate "Doe." Ann and her bosses cynically milk the story for all it's worth, until the made-up "John Doe" philosophy starts a whole political movement.
On a cruise to Cuba, Lulu Smith falls in love with Bob Grover. Back home, she breaks off the romance when he tells her he is married. Lulu has a baby but doesn't tell Bob, who turns out to be a rising politician. She passes herself off as the baby's nanny. When Bob learns what is going on, he adopts the little girl, not telling his wife or anyone else where she came from. Lulu gets a job at a newspaper. Things get complicated when the editor gets the dirt on Bob, but also wants to marry Lulu.
An industrialist is urged to run for President, but this requires uncomfortable compromises on both political and marital levels.