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Eight people are invited by an unsigned telegram to a penthouse apartment, where they find themselves locked in and greeted by their unknown host's voice via the radio, who explains that before the night is over each one will be die unless they manage to outwit the ninth guest, Death.
Holmes and Watson board a passenger train bound from London to Edinburgh, to guard the Star of Rhodesia, an enormous diamond worth a fortune belonging to an elderly woman of wealth; but within the first hour of the trip, the woman's son is murdered and the diamond stolen and any of the passengers in their car could be the killer thief.
Sherlock Holmes investigates when young women around London turn up murdered, each with a finger severed. Scotland Yard suspects a madman, but Holmes believes the killings to be part of a diabolical plot.
After being resurrected by grave robbers, Larry Talbot searches for Dr. Frankenstein in the hopes of being cured of his lycanthropy. The mad scientist may turn out to be dead, but his monster is just waiting to be found…
Young Gloria O'Connell falls in love with her neighbor, James Oliver. She is sent to a small town to stay with her three spinster aunts, while James becomes a newspaper reporter and arranges to write a story on the town and its large old-maid population. James pursues overweight "Hippo" Harger, a rival for Gloria's affections, and challenges him to a duel. When James' newspaper story appears, the disgruntled old maids hunt down the author. In a fit of anger, Gloria decides to marry "Hippo," but James rescues her at the office of the justice of the peace. The youthful lovers continue their relationship with their parents' understanding.
Marjorie Pope, who is engaged to Magnet, a wealthy suitor whom she does not love, elopes with Trafford, an inventor, after his airplane crashes on the grounds of her parents' rural home. Soon, however, Marjorie, irked by his dedication and idealism, persuades Trafford to market his wonderful invention, but her extravagance leads her into an affair with Sir Roderick. Trafford turns her out of their African home, but she returns to nurse him back to health when he is injured by a lion.
An inventor makes contact with Mars via television. The film is notable for using the 3-D process called Teleview, similar to today's alternating frame 3-D systems. Shown in 3-D only at the Selwyn Theater in New York City, it was previewed as Mars Calling at a trade and press screening on 13 October 1922, premiered as M.A.R.S. on 27 December 1922, and ran through 20 January 1923. A 2-D version was distributed as Radio-Mania in 1923–1924.
A convicted thief in Dartmoor prison hides the location of the stolen Bank of England printing plates inside three music boxes. When the innocent purchasers of the boxes start to be murdered, Holmes and Watson investigate.
In the midst of World War II, Sherlock Holmes rescues the Swiss inventor of a new bomb-sight from the Gestapo and brings him to England, where he quickly falls into the clutches of the evil Professor Moriarty.
The famous Borgia Pearl, a valuable gem with a history of bringing murder and misfortune to its owner since the days of the Borgias, is brought to London, thanks in part to Sherlock Holmes. But before long the jewel is stolen, due to an error on Holmes' part, and shortly thereafter, a series of horrible murders begin, the murderer leaving his victims with their spines snapped and surrounded by a mass of smashed china.