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Adrian Monk was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic (and still unsolved) murder of his wife Trudy, he developed an extreme case of obsessive-compulsive disorder. Now working as a private consultant, Monk continues to investigate cases in the most unconventional ways.
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Murphy Brown (Candice Bergen) is a recovering alcoholic who returns to the fictional newsmagazine FYI for the first time following a stay at the Betty Ford Clinic residential treatment center. Over 40 and single, she is sharp tongued and hard as nails. In her profession, she is considered one of the boys, having shattered many glass ceilings encountered during her career. Dominating the FYI news magazine, she is portrayed as one of America's hardest-hitting (though not the warmest or more sympathetic) media personalities.
Felicity Porter, a sensitive and intelligent girl from the San Francisco Bay Area, decides to give up a slot at Stanford University's pre-med program to follow her long time crush to college in New York City. Things get even more complicated when she meets her dorm's resident advisor and they fall in love.
Julia Sugarbaker, Mary Jo Shively, Charlene Frazier-Stillfield and Suzanne Sugarbaker are associates at their design firm, Sugarbaker and Associates. Julia is the owner and is very outspoken and strong-willed. Mary Jo is a divorced single-parent whom is just as strong-willed as Julia, but isn't as self-confident. Charlene is the naive and trusting farm girl from Poplar Bluff, Missouri. Suzanne is the self-centered ex-beauty queen whom has a number of wealthy ex-husbands.
Paul and Cate are raising their three children -- Bridget, Kerry and Rory -- which is no easy task. Oldest daughter Bridget is traversing the dating scene. Kerry is cute and smart, but she has a hard time getting in touch with her true feelings because of her lack of self-confidence. The youngest of the three children, and only boy, Rory is beginning to discover one of life's greatest mysteries -- girls.
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George raises daughter Carmen and dyslexic son Max with his wife Angie, after surviving a miserable, dysfunctional childhood at the hands of his neglectful alcoholic mother Benny.