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Confined to his Tahitian hut by the French colonial authorities in 1903, the painter Paul Gauguin is forced to paint a new masterpiece to save his five-year-old native son, while battling illness and torn between madness and sanity. In the course of these events, memories of the past, especially of his life and work at the Panama Canal, the place where his artistic career began and his guilt at abandoning his family in Paris, begin to haunt him.
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American retired Judge Randall Nemes and his hired gun, Gaspar, track down a con man posing as a priest in a small Colombian town only to be thrown off-course by a scrappy 16-year-old girl intent on reuniting with her sister in the United States.
Fresh out of prison, Ava's attempt to reclaim her drug operation collapses when she witnesses a brutal crime, forcing her to flee into a nightmarish underworld where allies are scarce and enemies multiply by the minute.
Medicine, money and morality clash when a hospital's Heart Transplant Selection Committee has only minutes to decide which of three patients on the transplant list will receive a heart that has suddenly become available.
Utah and his girlfriend Opal, are drug addicts living on the streets in rural Ohio. After getting recruited by body broker Wood and offered treatment in Los Angeles, Wood takes Utah under his wing and introduces him to treatment center mogul Vin. Wood and Vin bring Utah in on their lucrative and illegal dealings, where saving lives comes second to the bottom line.
Thomas Jacobs invents a way to watch people's memories from the inside. Going against his morals, he accepts an offer to enter a heroin addict's memories to literally see if he committed a crime. However,a malfunction causes his consciousness to become trapped inside the criminal's mind. He remains a prisoner in the addict's memories for more than four years until he discovers the possibility of escape.
Jim Douglass arrives in the small town of Rio Arriba in order to witness the hanging of the four men he believes murdered his wife. When the convicts escape, Jim tracks them into Mexico, determined to see that justice is done. But the farther Jim goes in his quest for vengeance, the more merciless he becomes, losing himself in an unrelenting spiral of hatred and violence.