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On the night of a once in a millennia event, the convergence of a planetary alignment and a lunar eclipse, 6 friends gather together to have a viewing party to celebrate. As the eclipse nears its peak, the group prepares to head to the roof only to be stopped in their tracks when they all receive an emergency alert telling them not to look at the moon. A glance out the window at the streets below sees everyone outside all staring straight up, seemingly transfixed. As the night continues, the friends' minds and bodies are tattered and beaten by a powerful, enigmatic force. As they scramble to figure out what is happening they begin to come face to face with the realization that they only know one thing for sure, don't look at the moon.
Anna suffers from agoraphobia so crippling that when a trio of criminals break into her house, she cannot bring herself to flee. But what the intruders don't realize is that agoraphobia is not her only psychosis.
An American school teacher in England drives past an abandoned car late one night, unaware that the driver was the victim of a murder. As she comes to terms with the realization, seemingly supernatural events start to affect the gothic manor she lives in with her husband.
On a secluded family farm, a mother suffers a psychotic break due to postpartum depression, forcing the eldest son to protect his sibling from the mother they have always known and loved.
An African American male is imprisoned and placed in solitary confinement after being found guilty of murdering his wife, as he's haunted by internal demons and his dead wife, and pushed to the breaking point by an abusive female guard.
After thugs brutalize a deaf-mute woman, the spirit of an Apache warrior takes over her lifeless body and sets out on a bloodthirsty quest for revenge.
A troubled young woman becomes obsessed with her mysterious new neighbor, who bears a striking resemblance to the girl's dead mother.
A fashion designer suffers from a mysterious illness that puzzles her doctors and frustrates her husband until help arrives in the form of a Filipino caregiver who uses traditional folk healing to reveal a horrifying truth.
Romulus, a misunderstood musician turned recluse hiding from personal demons in a New York City cave, finds the frozen body of a young drifter in a tree. The authorities, including his police officer daughter, claim the death is accidental. Romulus is convinced the man was murdered by a prominent art photographer but how can he prove he's right when everyone thinks he's insane?
As a police officer investigates the gruesome murder of her colleague, she discovers that a mysterious supernatural force is behind it.