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A medical school graduate takes an internship at a big city hospital, only to be subjected to a rigorous (and sometimes embarrassing) testing of his knowledge by the hospital's top dog, Dr. Leonard Gillespie.
Following an argument with his young protege, the curmudgeonly Dr. Gillespie dumps Jimmy Kildare in a street clinic, hoping to teach him a lesson. While working there Kildare meets pretty nurse Mary Lamont, and ends up treating a hoodlum with a gunshot wound. He purposely fails to write a report on it, and soon finds himself in a heap of trouble. Who else would come to his rescue but good old Dr. Gillespie?
Intern Kildare heals a millionaire's daughter and tricks Dr. Gillespie into taking a vacation.
An ice skater sues Kildare (Lew Ayres) for malpractice after his roadside first aid leaves her paralyzed.
Jimmy Kildare's impending nuptials are jeopardized by a diagnosis of possible epilepsy in his fiancee's brother.
A variety of predicaments arise to distract Dr. Kildare from his wedding to Nurse Mary Lamont.
Dr. Gillespie supports Kildare's crusade against their hospital's deal with a rival hospital.
Kildare tries brain surgery, advised by Dr. Gillespie, and faces a rival for nurse Lamont.
The doctor (Lionel Barrymore) has a Kansan (Van Johnson), an Australian and an Asian from Brooklyn to choose from.
In this 13th entry to the Dr. Kildare series, the medical staff of Blair General hospital are challenged with further dilemmas, not the least of which includes a prison inmate who Dr. Gillespie believes belongs instead in an insane asylum.