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Takeshi Hongo is a promising young man with a passion for motorcycle racing. However, his dreams are suddenly ruined when he gets kidnapped by Shocker, the evil secret organization planning to dominate the world. After being remodeled into a cyborg, Takeshi escapes and swears to protect the world from the inhuman monsters.
Four young physicians are assigned to the “Doctor Helicopter” system, the latest medical system where a medical team is dispatched to the patients via helicopter to provide medical care in the field as soon as possible. The doctors experience traumatic medical situations, deal with personal ambitions, and witness the fragility of life, all while growing personally and professionally.
Shinnosuke Tomari is a former elite police officer in the Metropolitan Police who, after an event that traumatized one of his colleagues, has been "demoted" into the Special Investigations Division, a group that looks into the stranger happenings in the city, particularly the "Heavy Acceleration" events that leave people unable to move that the public have termed the "Slowdown." When he is chosen by the Drive Driver and Tridoron, Shinnosuke transforms into Kamen Rider Drive and is tasked with battling the Roidmudes who wish to take over the world by eliminating humanity.
Kubozuka Yosuke and Kamenashi Kazuya play the roles of an avenger duo tied to their dark past. They are not champions of justice, moral teachers, or preachers. Instead, they are professional avengers. Behind the facade of running a small and ordinary old bookstore, Kamo and Tora seek revenge for victims and their families against villains who have escaped legal justice. But why? What drove them to become avengers? The duo targets ruthless murder cases by a rapist, a child abuser, and a family manipulator.