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Centered around typical Japanese food, a solitary salesman travelling through the country for business purposes, eats at its various establishments and experiences the various delicacies of Japanese cuisine.
The hosts explore different neighborhoods and izakayas, discussing various snacks and drinks. They share interesting trivia about the food and beverages, often accompanied by lively conversations with female guests and experts.
Celebrity guests are split into two teams to compete in various contests. One guest, known only to himself, is designated the "X-Man", and does his best to cause his team to lose the contests. At the end, all guests try to determine the X-Man's identity.
Edawakare is the driver of Sentaxi, a marvellous vehicle which is able to take a passenger back to his or her “life’s turning point”. His cool appearance is at odds with his talkative, meddlesome, sweet-toothed character. He gives advice to passengers who are flustered after failing in their life’s choice.
Daimon Michiko is a 37-year-old freelance surgeon who is part of a questionable “doctor placement service” that has her wander from hospital to hospital. The harsh environment at the hospitals led many doctors to retire from their positions, forcing hospitals to make use of said program to fill the empty spots at least temporary. However, Michiko doesn’t look like a doctor at all with her flashy clothes and eccentric attitude. In the first episode she raises objections to a certain operation which is planned to be done by the head of a hospital who hasn’t performed an operation for a very long time. This causes Michiko to incur odium at the hospital, however, everyone becomes frozen when Michiko points out the outdated skills of the director. She also holds a scrupulous compliance when it comes to her working hours, never does any unnecessary chores that don’t require a medical license, and couldn’t care less about the power struggles within the hospitals. Nobody knows how she acquired such a top-level skill that allows her to claim exorbitant sums as reward, but her private life is an even greater mystery to everyone around her. Tanaka plays a rookie surgeon, Uchida an anesthetist, Kishibe the head of the placement service, and Ito the head of the surgical department of this institution.