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In early 1900s London, a young Japanese woman enrolls in a famous art school, only to be surprised when rivalry with a gifted classmate becomes romance.
Natsuki Subaru, an ordinary high school student, is on his way home from the convenience store when he finds himself transported to another world. As he's lost and confused in a new world where he doesn't even know left from right, the only person to reach out to him was a beautiful girl with silver hair. Determined to repay her somehow for saving him from his own despair, Subaru agrees to help the girl find something she's looking for.
Maomao lived a peaceful life with her apothecary father. Until one day, she's sold as a lowly servant to the emperor's palace. But she wasn't meant for a compliant life among royalty. So when imperial heirs fall ill, she decides to step in and find a cure! This catches the eye of Jinshi, a handsome palace official who promotes her. Now, she's making a name for herself solving medical mysteries!
Gon, a young boy who lives on Whale Island, dreams of becoming a Hunter like his father, who left when Gon was still young.
Mina Tepeş, the Princess of the ancient covenant and ruler of all vampires, wants her race to stop hiding from the humans. Using her vast wealth, she has paid off Japan's entire national debt and by doing so, gained the right to create a district off Japan's coast that is to become the future haven to vampires worldwide. But when she finally attempts to make public the existence of vampires to the world some politicians, terrorists and rival factions are plotting to assassinate Mina before she has a chance to get Japan's and international recognition for the Vampire Bund. Now she must rely on her strength, cruelty and those closest to her, while trying to make a normal life.
In the near future, a sudden and unexplained sea rise has left much of human civilization underwater. Ikaruga Natsuki, a boy who lost his mother and one of his legs in an accident some years earlier, returns disillusioned from a harsh life in the big city to find his old countryside home half-swallowed by the sea. Left without a family, all he has to his name is the ship and submarine left to him by his oceanologist grandmother, and her debts. His only hope to restore the dreams for the future that he has lost is to take up an opportunity presented to him by the suspicious debt collector Catherine. They set sail to search the sunken ruins of his grandmother's laboratory in order to find a treasure rumor says she left there. But what they find is not riches or jewels; it is a strange girl lying asleep in a coffin at the bottom of the sea, Atri. Atri is a robot, but her appearance and her wealth of emotions would fool anyone into thinking she's a living, breathing human being.
Located in the center of a remote island, the Abyss is the last unexplored region, a huge and treacherous fathomless hole inhabited by strange creatures where only the bravest adventurers descend in search of ancient relics. In the upper levels of the Abyss, Riko, a girl who dreams of becoming an explorer, stumbles upon a mysterious little boy.
When a shapeshifting demon with a thirst for human flesh, known as "youma," arrives in Raki's village, a lone woman with silver eyes walks into town with only a sword upon her back. She is a "Claymore," a being manufactured as half-human and half-youma, for the express purpose of exterminating these monsters. After Raki's family is killed, the Claymore saves his life, but he is subsequently banished from his home. With nowhere else to go, Raki finds the Claymore, known as Clare, and decides to follow her on her journeys. As the pair travel from town to town, defeating youma along the way, more about Clare's organization and her fellow warriors comes to light. With every town cleansed and every demon destroyed, they come closer to the youma on which Clare has sought vengeance ever since she chose to become a Claymore.
After a mysterious virus wipes out ninety percent of humanity, vampires emerge from the recesses of the earth to enslave mankind, treating them like livestock. After growing tired of donating blood in exchange for protection, 12-year-old Yuichiro Hyakuya and his best friend Mikaela Hyakuya plot an escape along with the other orphans. After being the only successful runaway, Yuichiro joins the Moon Demon Company, an extermination unit of the Japanese Imperial Demon Army dedicated to killing off vampires.
Many centuries ago, man's Armageddon gave birth to the vampires' wrath. As man and immortal clash, a reality-shattering threat looms. Hope resides solely in a new breed of hunter operating under the Vatican's authority. The true battle between holiness and evil has begun.